San Francisco 49ers wide receiver Ricky Pearsall has missed the team's first practice of the week due to knee and ankle injuries.

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers

The San Francisco 49ers defense has been surviving despite injuries, and a lot of that credit has been given to Robert Saleh. Saleh was always expected to use the 49ers as a pit stop to regain his strong reputation as a head coaching candidate and parlay this into a new job.

Brandon Aiyuk has not played this season after suffering a torn ACL and MCL in Week 7 of the 2024 campaign, and San Francisco 49ers head coach Kyle Shanahan said Thursday he hasn't heard much from the wide receiver since the setback.

The San Francisco 49ers currently hold a playoff spot, and at least one analyst thinks they could be dangerous if they make it.

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in the throes of tense, tight division races where one more loss could eliminate them. Both are also trying to lock up playoff spots. And both face a daunting final three games against three potential playoff teams.

Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

CBS Sports analyst Mike Renner released his latest 2026 NFL mock draft, projecting the San Francisco 49ers to address a clear roster need: the interior offensive line.